기업소개

ceo이미지

CEO지요셉

약력

2020 ~ present : ㈜에이치이엠파마 대표(CEO)

2017 ~ 2019: ㈜홀잡펠이펙티브마이크로브스 최고기술경영자(CTO)

2016 ~ 2019: 차세대 녹색기술 연구원 연구교수, 한동대학교

2016 ~ 2018: 박사후 연구원, 이스라엘 테크니온 공과대학교 Technion Israel Institute of Technology, Faculty of biotechnology and food engineering

2012 ~ 2016: 차세대 녹색기술 연구원, (미생물) 박사 졸업, 한동대학교

2010 ~ 2012: 생명과학과 석사 졸업, 한동대학교

2001 ~ 2010: 국제경영학 학사 졸업, 한동대학교

2001 ~ 2010: 생명과학과 학사 졸업, 한동대학교

연구분야

· 미생물 안전성 및 기능성 검증 연구

· 숙주 장균총 분석 및 장균총 기반 질병 치료 연구

· 장균총 조절 및 장균총 조절을 위한 기능성 유용 미생물 (미생물 대사체) 연구

· 개인 맞춤형 프로바이오틱스 및 영양섭취 플랫폼 연구

수상내역

· 2012 슬로바키아, Probiotics and Prebiotics 국제 과학 컨퍼런스 젊은 과학자상

· 2013 슬로바키아, Probiotics and Prebiotics 국제 과학 컨퍼런스 젊은 과학자상

· 2013 미국 OMICS 컨퍼런스 젊은 과학자 상

· 2014 말레이시아 유익균 국제 컨퍼런스 젊은 과학자 상

· 2015 프랑스 Food Micro, 젊은 과학자 상 수상

· 2013 ~ 2015 : 한국 국립 중앙 연구소 박사과정 장학생

활동내역

· 2016 헝가리 부다페스트 Probiotics and Prebiotics 국제 과학 회의 초청 연사

· 2017 한국 부산 미생물 학회 (Cell Biotech Symposium) 국제 학술회의 초청 연사

· 2018 헝가리 부다페스트 Probiotics and Prebiotics 국제 과학 회의 초청 연사

· 2019 한국식품과학회(KoSFoST) 국제심포지엄 및 정기총회 (아모레퍼시픽 심포지엄) 초청 연사

논문

· Lee HJ, Yoon HS, Ji YS, Kim HN, Park HJ, Lee JE, et al., 2011. Functional properties of Lactobacillus strains isolated from kimchi. International Journal of Food Microbiology 145: 155-161.

·Yoon HS, Ju JH, Kim HN, Lee JE, Park HJ, Ji YS et al., 2011. Lactobacillus rhamnosus BFE 5264 and Lactobacillus Plantarum NR74 promote cholesterol excretion through the up-regulation of ABCG5/8 in Caco-2 cells. Probiotics and Antimicrobial Proteins 3: 194-203.

·Ji YS, Kim HN, Park HJ, Lee JE, Yeo SY, Yang JS, Park SY et al., 2012. Modulation of the murine microbiome with a concomitant anti-obesity effect by Lactobacillus rhamnosus GG and Lactobacillus sakei NR28. Beneficial Microbes 3: 13-22.

·Yoon HS, Ju JH, Kim HN, Park HJ, Ji YS, Lee JE et al., 2013. Reduction in cholesterol absorption in Caco-2 cells through the down-regulation of Niemann-Pick C1-like 1 by the putatitve probiotic strains Lactobacillus rhamnosus BFE5264 and Lactobacillus Plantarum NR74 from fermented foods. International Journal of Food Sciences and Nutrition 64: 44-52.

·Kim KS, Hoh DH, Ji YS, Do HK, Lee BJ and Holzapfel WH, 2013. Impact of light intensity, CO2 concentration and bubble size on growth and fatty acid composition of Arthrospira (Spirulina) platensis KMMCC CY-007. Biomass and Bioenergy 49: 181-187.

·Ji YS, Kim HN, Park HJ, Lee JE, Lee HJ, Shin HK et al., 2013. Functionality and safety of lactic bacterial strains from Korean kimchi. Food Control 31: 467-473.

·Lee SJ, Ji YS, Kim YJ, Lee BJ, Hong YC and Kim M, 2013. Plasma production by multi-phase alternating current underwater discharge and its applications to disinfection of micro-organisms. Desalination and Water Treatment 51: 6224-6229.

·Yang JS, Ji YS, Park HJ, Lee JE, Yeo SY, Shin HK and Holzapfel WH, 2014. Selection of functional lactic acid bacteria as starter cultures for the fermentation of Korean leek (Allium tuberosum Rottler ex Sprengel.). International Journal of Food Microbiology 191: 164-171.

·Kim KS, Choi JH, Ji YS, Park SY, Do HK, Whang CW et al., 2014. Impact of bubble size on growth and CO2 uptake of Arthrospira (Spirulina) platensis KMMCC CY-007. Bioresource Technology 170: 310-315. Park HJ, Yeo SY, Ji YS, Lee JE, Yang JS, Park SY et al., 2014. Autoinducer-2 associated inhibition by Lactobacillus sakei NR28 reduces virulence of enterohaemorrhagic Escherichia coli O157:H7. Food Control 45: 62-69.

·Yeo SY, Park HJ, Ji YS, Park SY, Yang JS, Lee JE et al., 2015. Influence of gastrointestinal stress on autoinducer-2 activity of two Lactobacillus species. FEMS Microbiology Ecology 91, fiv065.

·Kim BB, Park KY, JI YS, Park SY, Holzapfel WH, Hyun CK. 2016. Protective effects of Lactobacillus rhamnosus GG against dyslipidemia in high-fat diet-induced obese mice. Biochemical and Biophysical Research Communications: 473(2):530-6. doi: 10.1016/j.bbrc.2016.03.107. Epub 2016 Mar 23.

·Jung HY, Ji YS, Kim NR, Kim DY, Kim KT, Choi BH. 2016. A Fomitopsis pinicola Jeseng formulation has an antiobesity effect and protects against hepatic steatosis in mice with high-fat diet-induced obesity. Evidence-based Coplementary and Alternative Medicine Volume 2016, Article ID 7312472, 10 pages

·Park SY, Ji YS, Park HJ, Lee KY, Park HR, Beck BR, Shin HK, Holzapfel WH. 2016. Evaluation of functional properties of lactobacilli isolated from Korean white kimchi. Food Control 69: 5-12.

·Park SY, Ji YS, HY Jung, HJ Park, JH Kang, SH Choi et al., 2016. Lactobacillus plantarum HAC01 regulates gut microbitoa and adipose tissue accumulation in a diet-induced obesity murine model. Applied Microbiology and Biotechnology: 101(4):1605-1614. doi: 10.1007/s00253-016-7953-2. Epub 2016 Nov 17.

·Choi SH, Ji YS, Park SY, Mathara J, Holzapfel WH, Kang JH., 2017. Complete genome sequence of Lactobacillus rhamnosus BFE5264, isolated from Maasai Traditional Fermented Milk. Genome Announcements: doi: [10.1128/genomeA.00563-17]

·Kim MS, Kim B, Park H, Ji YS, Holzapfel W, Kim DY, Hyun CK., 2018. Long-term fermented soybean paste improves metabolic parameters associated with non-alcoholic fatty liver disease and insulin resistance in high-fat diet-induced obese mice. Biochemical and Biophysical Research Communications 495, 1744-1751.

·Jung HY, Kim B, Ji YS, Ryu HG, Park SY, Choi SH et al., 2018. Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice. Diabetes, Obesity and Metabolism, 20(7):1688-1701. doi: 10.1111/dom.13284. Epub 2018 Apr 14.

·Ji YS, Park SY, Park HR, Hwang EC, Shin HK, Pot B, Holzapfel WH., 2018. Modulation of active gut microbiota by Lactobacillus rhamnosus GG in a diet induced obesity murine model. Frontiers in Microbiology 10(9):710, doi:10.3389/fmicb.2018.00710

·Ji YS, Chung YM, Park SY, Jeong DH, Kim BJ, Holzapfel WH., 2018. Dose dependent anti-obesity effect of three different Lactobaillus sakei strains using a diet induced obese murine model. PeerJ Preprints, http://doi.org/10.7287/peerj.preprints.26959v1

·Park SY, Kang JH, Choi SH, Park HR, Hwang EC, Kang YG, Kim AR, Holzapfel WH., Ji YS., 2018. Cholesterol-lowering effect of Lactobacillus rhamnosus BFE5264 and its influence on the gut microbiome and propionate level in a murine model. PlLoS One 13(8): e0203150. http://doi.org/10.1371/journal.pone.0203150

·Hwang EC, Kang SW, Park HR, Park SY, Ji YS, Holzapfel WH., 2018. Differences in anxiety levels of various murine models in relation to the gut microbiota composition. Biomedicines, in-press

·Kim BB, Kwon JH, Kim MS, Park HR, Ji YS, Holzapfel WH, Hyun CK, 2018. Protective effects of Bacillus probiotics against high-fat diet-induced metabolic disorders in mice. PLoS One 13(12): e0210120.

·Ji YS, Chung YM, Park SY, Jeong DH, Kim BJ, Holzapfel WH, 2019. Dose dependent anti-obesity effect of three different Lactobaillus sakei strains using a diet induced obese murine model. PeerJ 7: e6651.

·Ji YS, Park SY, Chung YM, Kim B, Park HR, Hwang EC, Jeong D, Jung HY, Kim BJ, Hyung CK, Holzapfel WH, 2019. Amelioration of obesity-related biomarkers by Lactobacillus sakei CJLS03 in a high-fat diet-induced obese murine model. Scientific Reports 9: 6821.

·Jeong HY, Choi SH, Park GS, Ji YS, Park SY, Holzapfel WH et al., 2019. Comparative genomic analysis of Lactobacillus rhamnosus BFE5264, a probiotic strain isolated from traditional Maasai fermented milk. Microbiology and Biotechnology Letters 47(1): 25-33.

·Arellano, Karina; Vazquez, Jorge; Park, Haryung; Lim, Juhwan; Ji, Yosep; Kang, Hye-Ji; Cho, Donghyun; Jeong, Hyun Woo; Holzapfel, Wilhelm Heinrich; 2020. Safety Evaluation and Whole-Genome Annotation of Lactobacillus plantarum Strains from Different Sources with Special Focus on Isolates from Green Tea. Probiotics and antimicrobial proteins 12(3): 1057-1070.

·Han YJ, Park HR, Choi BR, Ji YS, Kwon EY, Choi MS, 2020. Alteration of Microbiome Profile by D-Allulose in Amelioration of High-Fat-Diet-Induced obesity in Mice. Nutrients 2020(12 ): 352

·Park HR, Cho DH, Huang EC, Seo JY, Kim WG, Todorov SD, Ji YS, Holzapfel WH, 2020. Amerlioration of alcohol induced gastric ulcers through the administration of Lactobacillus plantarum APSulloc 331261 isolated from green tea. Frontiers in Microbiology 11:420.

·Jeon MG, Kim TR, Lee JY, Kim HS, Ji YS, Holzapfel WH et al., 2020. Hepatoprotective Effects of Streptococcus thermophilus LM1012 in Mice Exposed to Air Pollutants. Journal of Medicinal Food 23(8): 852-861.

·Huang EC, Kim SK, Park HR, Park SY, Ji YS, Todorov SD, Lim SD, Holzapfel WH, 2020. Modulation of the Gut Microbiome and Obesity Biomarkers by Lactobacillus Plantarum KC28 in a Diet-Induced Obesity Murine Model. Probiotics and Antimicrobial Proteins https://doi.org/ 10.1007/s12602-020-09720-0

·Dioso CM, Vital P, Arellano K, Park HR, Todorov SD, Ji YS, Holzapfel WH, 2020. Do Your Kids Get What You Paid for? Evaluation of Commercially Available Probiotic Products Intended for Children in the Republic of the Philippines and the Republic of Korea. Foods 9(9): 1229.

·Park HR, Lee MK, Jeong DH, Park SY, Ji YS, Todorov SD, Holzapfel WH, 2020. Safety Evaluation and In vivo Strain-Specific Functionality of Bacillus Strains Isolated from Korean Traditional Fermented Foods. Probiotics and Antimicrobial Proteins https://doi.org/10.1007/s12602-020-09672-5

·Kim TR, Choi KS, Ji YS, Holzapfel WH, Jeon MG, 2020. Anti-inflammatory effects of Lactobacillus reuteri LM1071 via MAP kinase pathway in IL-1β-induced HT-29 cells. Journal of Animal Science and Technology 62(6): 864.

뒤로가기

  • 2021

    5월

    (주)에이치이엠파마로 사명 변경

    2월

    GMP 원료의약품 생산 설비 완공

    1월

    암웨이 밸런스 위드인 이뮤니티 출시

  • 2020

    11월

    우울증 유효성평가 임상 시작

    9월

    LARS 유효성평가 임상 시작

    ISO 9001 품질경영시스템 인증

    4월

    (주)에이치이엠으로 상호 변경

    포스트시너지 서비스 런칭

    3월

    장내미생물 - 대사체 연구 서비스 런칭

    1월

    Access Business Group 오마이것 서비스 판매 독점 계약

  • 2019

    9월

    코스맥스 엔비티와 유산균 연구 교류와 제품 개발 및 판매 협력에 대한 사업 계약

    8월

    포항 무균쥐 연구 시설 완공

  • 2018

    9월

    한국벤처기업 인증

    6월

    기업부설연구소 인정

    4월

    HEM 수원 광교 차세대융합기술원 지사 설립

  • 2017

    9월

    LARS 유효성평가 임상 시작

    8월

    ㈜Lactomason과 MOU 체결 및 기술이전 진행

    5월 ~ 현재

    이스라엘 Better Air, 총 $600,000 규모 환경 정화용 유용 미생물 기술 이전 계약 수주

    1월

    ㈜홀잡펠이펙티브마이크로브스 설립

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주소
경기도 수원시 영통구 창룡대로 256번길 77 에이스광교 타워 3차 404호 16229
전화
1899-4258
팩스
031-5186-6074
Email
hem@hempharma.bio

에이치이엠파마의 미래를 책임질 기술들에 대한 기반연구가 이루어집니다.
CTO를 중심으로 대학 연구인력과 협력하고 있습니다.

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대한민국 경상북도 포항시 북구 흥해읍 한동로 558 한동대학교 창업보육센터 204호 37554
전화
054-260-3122
팩스
054-700-0787
Email
hem@hempharma.bio
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